Neal C E, Swenson L C, Fanning J, Texter J H
Department of Radiology, Memorial Medical Center, Springfield, IL 62781.
Semin Nucl Med. 1993 Apr;23(2):114-26. doi: 10.1016/s0001-2998(05)80092-3.
Radioimmunoscintigraphy (RIS)--using radiolabeled monoclonal antibodies (MoAbs) to image disease--is a growing subspecialty of nuclear medicine. RIS of the reproductive tracts of men and women has shown encouraging results in imaging both primary lesions and metastases of these cancers. Ovarian cancer is the most fatal gynecologic cancer in the United States, and prostate cancer is the most prevalent form of cancer in men. Several MoAbs against reproductive tumor antigens were used with limited success in clinical trials before 1989. Most recently, MoAbs CYT-103 (satumomab pendetide) and OV-TL 3 have shown promise as safe, sensitive imaging tools for ovarian cancer. Although to date more agents have been used to image ovarian carcinoma than prostate cancer, research has been restimulated in prostate carcinoma imaging because of development of a promising MoAb conjugate, CYT-356. Radionuclide indium-111 appears to be the most promising radiolabeled to date for ovarian and prostate carcinoma RIS performed in the United States. In future clinical trials, consideration of safety issues and a standardization of methods among institutions using RIS are needed before the use of MoAb technology in cancer imaging will become routine. Comparative studies with more traditional methods like computed tomography are needed, as well as more trials comparing radioimmunoscintigraphic findings with pathological evidence.
放射免疫闪烁显像（RIS）——利用放射性标记的单克隆抗体（MoAb）对疾病进行成像——是核医学中一个不断发展的亚专业领域。对男性和女性生殖道进行放射免疫闪烁显像在对这些癌症的原发灶和转移灶成像方面已显示出令人鼓舞的结果。卵巢癌是美国最致命的妇科癌症，前列腺癌是男性中最常见的癌症形式。1989年之前，几种针对生殖肿瘤抗原的单克隆抗体在临床试验中的应用效果有限。最近，单克隆抗体CYT - 103（沙妥莫单抗）和OV - TL 3已显示出有望成为用于卵巢癌的安全、灵敏的成像工具。尽管迄今为止用于卵巢癌成像的试剂比用于前列腺癌成像的试剂更多，但由于一种有前景的单克隆抗体偶联物CYT - 356的研发，前列腺癌成像研究再次受到推动。放射性核素铟 - 111似乎是目前在美国进行卵巢癌和前列腺癌放射免疫闪烁显像最有前景的放射性标记物。在未来的临床试验中，在将单克隆抗体技术用于癌症成像成为常规做法之前，需要考虑安全问题并使使用放射免疫闪烁显像的各机构之间的方法标准化。需要与计算机断层扫描等更传统的方法进行比较研究，以及更多将放射免疫闪烁显像结果与病理证据进行比较的试验。
