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油酸所致栓塞性肺病。一项系统形态学研究。

Embolic pneumopathy induced by oleic acid. A systematic morphologic study.

作者信息

Derks C M, Jacobovitz-Derks D

出版信息

Am J Pathol. 1977 Apr;87(1):143-58.

PMID:851163
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2032063/
Abstract

This paper presents a systematic study of acute and chronic pulmonary lesions resulting from a single intravenous injection of oleic acid and a new fibrosis lung model is proposed: pulmonary interstitial fibrosis is obtained by means of a number of oleic acid intravenous injections. Nineteen adult dogs received 0.045 g/kg or 0.09 g/kg of oleic acid. A systematic morphologic study was carried out after 1, 2, 3, 4, 6, 12, 24, and 48 hours and 1, 2 and 4 weeks. Eleven other adult dogs received weekly one injection of 0.09 g/kg of pure oleic acid over a period of 1 to 3 months. Examination of the lung was carried out by means of light and electron microscopy and morphometry. An early stage characterized by the formation of thrombosis and cellular necrosis was followed by a repair stage with the proliferation of Type 2 cells and fibrotic foci in the subpleural areas. Lipid staining with Sudan IV allowed the onset and disappearance of lipid-laden macrophages to be ascertained. The late stage showed pulmonary fibrosis. The extent of the lesions is related to the number of oleic acid injections. Since interstitial pulmonary fibrosis invariably appeared, and only 2 dogs out of 11 died, the model is satisfactory for pathologist and physiologist.

摘要

本文对单次静脉注射油酸所致的急慢性肺部病变进行了系统研究，并提出了一种新的肺纤维化模型：通过多次静脉注射油酸获得肺间质纤维化。19只成年犬接受了0.045g/kg或0.09g/kg的油酸。在1、2、3、4、6、12、24和48小时以及1、2和4周后进行了系统的形态学研究。另外11只成年犬在1至3个月的时间里每周接受一次0.09g/kg纯油酸的注射。通过光镜、电镜和形态测量法对肺进行检查。早期以血栓形成和细胞坏死为特征，随后是修复期，伴有Ⅱ型细胞增殖和胸膜下区域的纤维化灶。用苏丹IV进行脂质染色可确定含脂巨噬细胞的出现和消失。晚期表现为肺纤维化。病变程度与油酸注射次数有关。由于总是出现肺间质纤维化，且11只犬中只有2只死亡，该模型对病理学家和生理学家来说是令人满意的。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbea/2032063/10aac3c4cba0/amjpathol00398-0161-c.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbea/2032063/db38e46b372f/amjpathol00398-0165-a.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbea/2032063/581076106e50/amjpathol00398-0162-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbea/2032063/48332c2fdc91/amjpathol00398-0162-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbea/2032063/582780a4cc47/amjpathol00398-0166-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbea/2032063/021a46a0378e/amjpathol00398-0163-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbea/2032063/4c58907c2bca/amjpathol00398-0163-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbea/2032063/d915ccec9707/amjpathol00398-0164-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbea/2032063/58e47487a102/amjpathol00398-0164-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbea/2032063/db38e46b372f/amjpathol00398-0165-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbea/2032063/bd422c7cd270/amjpathol00398-0165-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbea/2032063/c76eed9acce2/amjpathol00398-0161-a.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbea/2032063/10aac3c4cba0/amjpathol00398-0161-c.jpg

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