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大鼠左心室实验性梗死灶周边缺血区的超微结构变化

Ultrastructural changes in the ischemic zone bordering experimental infarcts in rat left ventricles.

作者信息

Page E, Polimeni P I

出版信息

Am J Pathol. 1977 Apr;87(1):81-104.

PMID:851166
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2032068/
Abstract

Ultrastructural changes in myocardial cells from the ischemic border of infarcts (produced in rat left ventricles by ligating the anterior coronary artery in vivo) were examined 1 to 24 hours after ligation. Twenty-four hours after ligation, irreversibly injured cells showed a selective spreading of Z-band material over the I band; disappearance of M bands, prominent N bands, and disassembly of A bands were also noteworthy. Sixty minutes after ligation the cells of the ischemic border were ultrastructurally normal except for paradoxically relaxed sarcomeres, indicative of an inability to contract in response to the calcium influx produced by osmium tetroxide; progressive vacuolization of this zone was evident after 4 to 12 hours. Paradoxical relaxation may be an ultrastructural correlate of acute ischemic "pump failure".

摘要

对在体结扎大鼠左冠状动脉造成梗死灶缺血边缘区的心肌细胞进行超微结构变化检测，检测时间为结扎后1至24小时。结扎24小时后，不可逆损伤的细胞显示Z带物质选择性地扩展至I带；M带消失、N带突出以及A带解体也值得注意。结扎60分钟后，缺血边缘区的细胞超微结构正常，只是肌节出现反常松弛，这表明细胞无法对四氧化锇引发的钙内流做出收缩反应；4至12小时后，该区域逐渐出现空泡化。反常松弛可能是急性缺血性“泵衰竭”的超微结构相关表现。

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