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[实验性颅脑创伤中脂质过氧化过程及脑琥珀酸脱氢酶活性]

[Lipid peroxidation processes and activity of brain succinate dehydrogenase in experimental craniocerebral trauma].

作者信息

Demchuk M L, Medvedev A E, Promyslov M Sh, Gorkin V Z

出版信息

Vopr Med Khim. 1993 Mar-Apr;39(2):23-5.

PMID:8511880
Abstract

A statistically significant decrease in the activity of succinate dehydrogenase (SDH) was found in the rabbit brain after craniocerebral injury. The decrease in the activity of brain SDH was not shown to result from "competitive inhibition" by malonate accumulated after activation of lipid peroxidation. The activity of brain SDH was normalized by directed modification of the function of the central nervous system via administration of phenamine (amphetamine) into the injured animals.

摘要

在兔脑遭受颅脑损伤后,发现琥珀酸脱氢酶(SDH)的活性有统计学意义的下降。脑SDH活性的下降并非由脂质过氧化激活后积累的丙二酸的“竞争性抑制”所致。通过向受伤动物体内注射苯丙胺(安非他明)直接改变中枢神经系统的功能,脑SDH的活性恢复正常。

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