Sdvigova A G, Panasenko O M, Luk'iashchenko V I, Sergienko V I, Lopukhin Iu M
Vopr Med Khim. 1993 Mar-Apr;39(2):30-3.
Atherosclerotic lesion of the aorta and lipid peroxidation (LPO) in blood and in lipoproteins produced in hepatocytes were studied in rabbits with experimental atherosclerosis maintained on a diet enriched in polyunsaturated fatty acids containing in corn oil (2 ml/kg daily during 30 days) and antioxidants alpha-tocopherol and carnosine (2.5 mg/kg and 50 mg/kg, respectively, daily during 30 days). This diet exhibited a hypocholesterolemic effect accompanied by approximately a 10-fold decrease of the impaired aortic area, as well as lowered content of 2-thiobarbituric acid-positive LPO products occurring in blood and, especially, in apoB lipoproteins. The antioxidant-containing diet decreased distinctly the content of LPO products both in the liver tissue homogenate and lipoprotein fraction (d < 1.065 g/cm3) produced by hepatocytes during 30-min perfusion of liver tissue. The findings suggest that the diet enriched in polyunsaturated fatty acids and antioxidants contributed to a decrease of LPO products content in the blood serum and apoB lipoproteins as well as to the inhibition of lipoprotein oxidation during their synthesis in liver cells; the diet may be recommended for the prophylaxis and treatment of atherosclerosis.
在实验性动脉粥样硬化的兔子中，研究了主动脉的动脉粥样硬化病变以及血液和肝细胞产生的脂蛋白中的脂质过氧化（LPO）情况。这些兔子食用富含玉米油中所含多不饱和脂肪酸的饮食（每天2毫升/千克，持续30天）以及抗氧化剂α-生育酚和肌肽（分别为每天2.5毫克/千克和50毫克/千克，持续30天）。这种饮食呈现出降胆固醇作用，同时主动脉受损面积大约减少了10倍，血液中尤其是载脂蛋白B脂蛋白中2-硫代巴比妥酸阳性LPO产物的含量也降低了。含抗氧化剂的饮食显著降低了肝组织匀浆和肝细胞在肝组织30分钟灌注过程中产生的脂蛋白部分（d < 1.065克/立方厘米）中LPO产物的含量。研究结果表明，富含多不饱和脂肪酸和抗氧化剂的饮食有助于降低血清和载脂蛋白B脂蛋白中LPO产物的含量，并抑制肝细胞合成脂蛋白过程中的脂蛋白氧化；这种饮食可推荐用于动脉粥样硬化的预防和治疗。
