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支气管成形术和血管成形术在支气管源性癌治疗中的应用

Bronchoplastic and angioplastic techniques in the treatment of bronchogenic carcinoma.

作者信息

Maggi G, Casadio C, Pischedda F, Cianci R, Ruffini E, Filosso P

机构信息

Department of Thoracic Surgery, University of Torino, Italy.

出版信息

Ann Thorac Surg. 1993 Jun;55(6):1501-7. doi: 10.1016/0003-4975(93)91098-8.

Abstract

From 1979 to 1991, 51 bronchoplasties, 18 angioplasties, and 4 combined broncho-angioplasties were performed for bronchogenic carcinoma. Sixteen patients underwent operation because of compromised pulmonary function; bronchoplasty, angioplasty, or the combined procedure was performed in the remaining 57 patients because of a suitable anatomic location of the neoplasm. Twenty-four patients had stage I disease, 32 stage II, and 17 stage IIIa. Three patients died postoperatively (3.65%). Major postoperative complications occurred in 20 patients (27.3%) (10 early, and 10 late). A completion pneumonectomy was required in 4 patients (5.4%), 2 for anastomotic stricture, 1 because of vascular thrombosis after angioplasty, and 1 for local recurrence after angioplasty. Three-year and 5-year survival rates for the entire group were 55.4% and 40.8%, respectively. One-year and 3-year survival rates after angioplasty were 78.6% and 31.4%. Of the 4 patients who underwent a combined bronchoangioplastic procedure, 1 died after 23 months and 3 are alive and well after 11, 15, and 20 months. Survival was more favorable in the combined N0-N1 group (62% and 43.1%) than in the N2 group (23.4%), but the difference was not significant (p < 0.2). Three-year survival after angioplasty was found to be lower than, although not significantly different from, the overall 3-year survival rate (31.4% versus 55.4%; p = not significant). No statistically significant differences were found among survival rates of patients with compromised and noncompromised pulmonary reserve. We conclude that bronchoplastic and angioplastic procedures are valid techniques as curative operations in carefully selected patients with bronchogenic carcinoma.(ABSTRACT TRUNCATED AT 250 WORDS)

摘要

1979年至1991年期间,对支气管肺癌患者实施了51例支气管成形术、18例血管成形术以及4例支气管-血管联合成形术。16例患者因肺功能受损接受手术;其余57例患者因肿瘤具有合适的解剖位置而接受了支气管成形术、血管成形术或联合手术。24例患者为Ⅰ期疾病,32例为Ⅱ期,17例为Ⅲa期。3例患者术后死亡(3.65%)。20例患者(27.3%)出现了主要术后并发症(10例为早期并发症,10例为晚期并发症)。4例患者(5.4%)需要进行全肺切除术,2例是由于吻合口狭窄,1例是因为血管成形术后血管血栓形成,1例是因为血管成形术后局部复发。整个组的3年和5年生存率分别为55.4%和40.8%。血管成形术后1年和3年生存率分别为78.6%和31.4%。接受支气管-血管联合成形术的4例患者中,1例在23个月后死亡,3例分别在11、15和20个月后存活且状况良好。N0-N1联合组的生存率(62%和43.1%)高于N2组(23.4%),但差异无统计学意义(p < 0.2)。血管成形术后3年生存率低于总体3年生存率,尽管差异无统计学意义(31.4%对55.4%;p = 无统计学意义)。肺储备功能受损和未受损患者的生存率之间未发现统计学上的显著差异。我们得出结论,支气管成形术和血管成形术是精心挑选的支气管肺癌患者有效的根治性手术技术。(摘要截选至250词)

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