Cohen H L, Porjesz B, Begleiter H
Department of Psychiatry, State University of New York Health Science Center Brooklyn, Brooklyn, New York 11203.
Neuropsychopharmacology. 1993 Jun;8(4):365-70. doi: 10.1038/npp.1993.36.
The present investigation examined the effects of placebo (P), low-dose (LD), and high-dose (HD) ethanol on electroencephalographic (EEG) activity in 21 healthy, adult males (X = 22.7 years). Only one condition (P, LD, or HD) was presented per day and the condition order was randomized. For each subject, blood-alcohol levels measured via breathalyzer and EEG activity, using the entire 10/20 International System, were recorded both prior to and at intervals of 35, 70, 105, and 140 minutes after P, LD, or HD administration. The Fast Fourier Transform was used to calculate power spectral densities for each EEG recording. Measures of the relative areas under the power spectral curve were made for each of the following frequency bands: slow alpha (7.5 to 10 Hz); fast alpha (10.5 to 13.0 Hz); slow beta (13.5 to 19.5 Hz); and fast beta (20 to 26 Hz) at electrodes F3, F4, C3, C4, P3, P4, O1, and O2. Repeated-measures multivariate analysis of variance performed on normalized relative area values revealed that ethanol had significant effects on EEG activity at anterior sites: frontal (F3, F4) and central (C3, C4) that presented as increased activity in the slow alpha frequency band. These results suggest a differential responsivity of both cortical region and EEG frequency band to the effects of ethanol ingestion.
本研究考察了安慰剂（P）、低剂量（LD）和高剂量（HD）乙醇对21名健康成年男性（平均年龄X = 22.7岁）脑电图（EEG）活动的影响。每天只呈现一种情况（P、LD或HD），情况呈现顺序随机。对于每个受试者，在给予P、LD或HD之前以及给药后35、70、105和140分钟时，使用完整的10/20国际系统记录通过呼吸酒精检测仪测量的血液酒精水平和EEG活动。使用快速傅里叶变换计算每次EEG记录的功率谱密度。针对以下每个频段，在电极F3、F4、C3、C4、P3、P4、O1和O2处测量功率谱曲线下的相对面积：慢α波（7.5至10 Hz）；快α波（10.5至13.0 Hz）；慢β波（13.5至19.5 Hz）；快β波（20至26 Hz）。对标准化相对面积值进行重复测量多变量方差分析，结果显示乙醇对前位部位（额叶（F3、F4）和中央（C3、C4））的EEG活动有显著影响，表现为慢α波频段活动增加。这些结果表明，皮层区域和EEG频段对乙醇摄入的影响具有不同的反应性。
