Dargent P, Breart G
INSERM Unité 149, Villejuif, France.
Curr Opin Rheumatol. 1993 May;5(3):339-45. doi: 10.1097/00002281-199305030-00013.
Recent osteoporosis research has been oriented increasingly toward understanding the determinants of peak bone mass acquisition during childhood and adolescence. Genetic factors may account for approximately half of the variability in peak femoral bone mass density, and racial differences in bone mass have been shown to appear early in life. Physical activity appears to play an important role in increasing bone mass during childhood. Most fractures in the elderly have been found to be associated with reduced bone mass and could therefore be considered osteoporotic. Retrospective reviews of medical records from residents of Rochester, Minnesota, suggest that approximately one third of women with vertebral deformities seek medical attention. Other cross-sectional data suggest that vertebral deformities cause substantial back pain and disability only if vertebral height ratios fall 4 SD below the mean.
近期骨质疏松症研究越来越倾向于了解儿童期和青春期峰值骨量获取的决定因素。遗传因素可能约占股骨峰值骨密度变异性的一半，且已表明骨量的种族差异在生命早期就已出现。身体活动似乎在儿童期增加骨量方面发挥着重要作用。已发现老年人的大多数骨折与骨量减少有关，因此可被视为骨质疏松性骨折。对明尼苏达州罗切斯特市居民病历的回顾性研究表明，约三分之一有椎体畸形的女性会寻求医疗帮助。其他横断面数据表明，只有当椎体高度比低于平均值4个标准差时，椎体畸形才会导致严重的背痛和残疾。
