Gallacher S J
University Department of Medicine, Glasgow Royal Infirmary, Scotland, UK.
Curr Opin Rheumatol. 1993 May;5(3):351-6. doi: 10.1097/00002281-199305030-00015.
In this review, recent studies on the etiology and pathogenesis of Paget's disease, with particular attention to the apparent familial clustering of cases and the possibility of a causal role for viral infection, are discussed. The role of biochemical markers of bone turnover is explored, as well as the value of imaging in confirming the diagnosis, monitoring the effects of therapy, and assessing complications. The bisphosphonates are widely used in the treatment of Paget's disease; experience with newer, more potent second- and third-generation bisphosphonates, as well as potential future roles for calcitonin, are described. Studies on some of the orthopedic effects of Paget's disease are also presented.
在本综述中，讨论了关于佩吉特病病因和发病机制的近期研究，尤其关注病例明显的家族聚集性以及病毒感染可能起到的因果作用。探讨了骨转换生化标志物的作用，以及影像学在确诊、监测治疗效果和评估并发症方面的价值。双膦酸盐被广泛用于治疗佩吉特病；描述了新型、更有效的第二代和第三代双膦酸盐的使用经验，以及降钙素未来可能发挥的作用。还介绍了关于佩吉特病一些骨科影响的研究。
