Kitagawa H, Yasuda K, Sasaki Y
Laboratory of Internal Medicine, Faculty of Agriculture, Gifu University, Japan.
J Vet Med Sci. 1993 Apr;55(2):275-80. doi: 10.1292/jvms.55.275.
Blood gases were analyzed in dogs with pulmonary heartworm (HW) disease. The arterial oxygen tension (PaO2) in dogs with mild signs of dirofilariasis (mildly affected group, n = 48, 85.7 +/- 8.2 mmHg) and in dogs with signs of right heart failure (severely affected group, n = 13, 76.4 +/- 11.6 mmHg) was lower (p < 0.01) than in dogs without HW infection (HW-free group, n = 19, 91.5 +/- 7.3 mmHg). Only 2 dogs in the severely affected group had a PaO2 less than 60 mmHg. The arterial carbon dioxide tension (PaCO2, p < 0.01) and mixed venous O2 (p < 0.01) and CO2 (p < 0.01) tensions were lower, and alveolar-arterial oxygen difference (AaDO2, p < 0.01) was greater in the severely affected group than in the HW-free and mildly affected groups. Arterial pH and bicarbonate (HCO3-) concentrations were lower (p < 0.01) in both affected groups than in the HW-free groups. The anion gap level was not different among the 3 groups. Serum lactic acid level in the severely affected group was higher (p < 0.01) than in the HW-free and mildly affected groups. However, a slightly higher serum lactic acid concentration was found only in 2 dogs of the severely affected group (3.84 mmol/l and 3.82 mmol/l). The PaO2 (r = -0.62) and AaDO2 (r = 0.66) correlated significantly (p < 0.01) with mean pulmonary arterial pressure. One week after HW removal, blood gases, pH and HCO3- concentration remained unchanged in the mildly affected group. In the severely affected group, blood gas values were the same, but pH and HCO3- concentration improved slightly.
对患有肺动脉心丝虫（HW）病的犬进行了血气分析。患有轻度恶丝虫病体征的犬（轻度感染组，n = 48，动脉血氧分压[PaO2]为85.7±8.2 mmHg）和患有右心衰竭体征的犬（重度感染组，n = 13，动脉血氧分压为76.4±11.6 mmHg）的动脉血氧分压低于未感染HW的犬（无HW感染组，n = 19，动脉血氧分压为91.5±7.3 mmHg）（p < 0.01）。重度感染组中只有2只犬的动脉血氧分压低于60 mmHg。重度感染组的动脉血二氧化碳分压（PaCO2，p < 0.01）、混合静脉血氧分压（p < 0.01）和二氧化碳分压（p < 0.01）较低，且肺泡 - 动脉血氧分压差（AaDO2，p < 0.01）高于无HW感染组和轻度感染组。两个感染组的动脉血pH值和碳酸氢盐（HCO3-）浓度均低于无HW感染组（p < 0.01）。三组之间阴离子间隙水平无差异。重度感染组的血清乳酸水平高于无HW感染组和轻度感染组（p < 0.01）。然而，仅在重度感染组的2只犬中发现血清乳酸浓度略高（分别为3.84 mmol/L和3.82 mmol/L）。动脉血氧分压（r = -0.62）和肺泡 - 动脉血氧分压差（r = 0.66）与平均肺动脉压显著相关（p < 0.01）。去除HW一周后，轻度感染组的血气、pH值和HCO3-浓度保持不变。在重度感染组中，血气值相同，但pH值和HCO3-浓度略有改善。
