Quintiliani R, Nightingale C H, Sullivan M C
Division of Infectious Diseases and Immunology/Allergy, Hartford Hospital, Connecticut.
Clin Ther. 1993;15 Suppl A:44-9.
Because they were almost always used in combination with an aminoglycoside, piperacillin and mezlocillin were considered therapeutic alternatives at Hartford Hospital, a 900-bed teaching facility. To determine an appropriate comparative dose, the bactericidal activities of 5 gm of mezlocillin and 4 gm and 3 gm of piperacillin were compared. The results demonstrated that 4 gm of piperacillin possessed stronger bactericidal activity than either 3 gm of piperacillin or 5 gm of mezlocillin. Hartford Hospital has since approved an antibiotic management program using 4 gm of piperacillin every 8 hours, thereby reducing the daily cost of antibiotic therapy. The modified program offers the hospital measurable cost savings without jeopardizing the quality of care.
由于哌拉西林和美洛西林几乎总是与氨基糖苷类药物联合使用，在拥有900张床位的教学机构哈特福德医院，它们被视为治疗替代药物。为了确定合适的对比剂量，比较了5克美洛西林以及4克和3克哌拉西林的杀菌活性。结果表明，4克哌拉西林的杀菌活性强于3克哌拉西林或5克美洛西林。此后，哈特福德医院批准了一项抗生素管理方案，每8小时使用4克哌拉西林，从而降低了抗生素治疗的每日成本。修改后的方案在不影响护理质量的情况下为医院节省了可观的费用。
