Lurie S, Katz Z, Insler V
Department of Obstetrics and Gynecology, Kaplan Hospital, Rehovot, Israel.
Contraception. 1993 May;47(5):475-81. doi: 10.1016/0010-7824(93)90099-s.
The efficacy of extraovular prostaglandin E2 and intra-amniotic prostaglandin F2 alpha for pregnancy termination in midtrimester was compared. A retrospective review of pregnancy termination in midtrimester using intra-amniotic instillation of 40 mg of prostaglandin F2 alpha (n = 133) or extraovular instillation of prostaglandin E2 at a rate of 500 micrograms/hour (n = 81) was performed. Both groups had a similar mean induction-to-abortion interval (19.5 +/- 19.9 and 20.9 +/- 18.2 hours for extraovular PGE2 and intra-amniotic PGF2 alpha, respectively) and a similar success rate of abortion within the first 24 hours of initial treatment (84.0% for extraovular PGE2 and 76.7% for intra-amniotic PGF2 alpha). The two groups had a similar and low (9.8%) incidence of complications. It is concluded that either of the methods used in the study (i.e. extraovular PGE2 or intra-amniotic PGF2 alpha) can be used safely and effectively for pregnancy termination in midtrimester.
比较了羊膜外前列腺素E2和羊膜腔内前列腺素F2α在孕中期终止妊娠的疗效。对孕中期终止妊娠进行了回顾性研究，其中羊膜腔内注入40mg前列腺素F2α（n = 133），或羊膜外以500微克/小时的速率注入前列腺素E2（n = 81）。两组的平均引产至流产间隔相似（羊膜外PGE2和羊膜腔内PGF2α分别为19.5±19.9小时和20.9±18.2小时），且初始治疗后24小时内的流产成功率相似（羊膜外PGE2为84.0%，羊膜腔内PGF2α为76.7%）。两组并发症发生率相似且较低（9.8%）。结论是，该研究中使用的任何一种方法（即羊膜外PGE2或羊膜腔内PGF2α）均可安全有效地用于孕中期终止妊娠。
