Gichangi P B, Nyongo A O, Temmerman M
Department of Human Pathology, University of Nairobi.
East Afr Med J. 1993 Feb;70(2):85-9.
The relationship between placental characteristics, including weight and inflammation, and pregnancy outcome was examined as part of a case control study looking into the impact of maternal HIV-1 infection on pregnancy outcome. Cases defined as low birth weight (< 2500g) or stillbirth deliveries, were compared to controls defined as mothers who delivered a live born neonate weighing 2500g or more. The mean placental weight and the mean foetal/placental weight ratio were significantly lower in cases (n = 253) than in controls (n = 216) (p < .05). Placental inflammation (chorioamnionitis) was significantly associated with prematurity (p < .001) and with stillbirth (p < .05), maternal HIV-1 antibody being a risk factor for chorioamnionitis in the preterm group. These data support a correlation between placental weight and pregnancy outcome, and suggest that maternal HIV-1 infection is a risk factor for chorioamnionitis in HIV-1 seropositive preterm deliveries.
作为一项病例对照研究的一部分，该研究旨在探讨孕产妇HIV-1感染对妊娠结局的影响，研究了包括胎盘重量和炎症在内的胎盘特征与妊娠结局之间的关系。将定义为低出生体重（<2500g）或死产的病例与定义为分娩体重2500g或以上活产新生儿的母亲作为对照进行比较。病例组（n = 253）的平均胎盘重量和平均胎儿/胎盘重量比显著低于对照组（n = 216）（p <.05）。胎盘炎症（绒毛膜羊膜炎）与早产（p <.001）和死产（p <.05）显著相关，孕产妇HIV-1抗体是早产组绒毛膜羊膜炎的一个危险因素。这些数据支持胎盘重量与妊娠结局之间的相关性，并表明孕产妇HIV-1感染是HIV-1血清学阳性早产中绒毛膜羊膜炎的一个危险因素。
