Predicting success of gamete intrafallopian transfer.

OBJECTIVES

To examine seminal parameters predictive for success in a cycle of GIFT and to construct an algorithm using pertinent seminal data as well as easily obtained historical data to predict pregnancy and viable pregnancy rates.

DESIGN

A retrospective study of 544 cycles in 376 couples.

SETTING

A private IVF-ET and GIFT center.

PATIENTS

Couples in a GIFT program with a mean of 53.6 months of infertility who had failed to conceive with other therapies.

INTERVENTIONS

Gamete intrafallopian transfer.

MAIN OUTCOME MEASURES

Pregnancy as a function of laboratory historical data with emphasis on seminal parameters.

RESULTS

Motility was the only seminal parameter that was predictive. Success was correlated with the number of oocytes returned and inversely related to female age. An algorithm to predict pregnancy in a GIFT cycle as well as viable pregnancy was constructed.

CONCLUSIONS

Motility is the only seminal parameter predictive for success in a GIFT cycle. An easily programmable algorithm can be constructed to help patient and physician decide on the appropriateness of GIFT for each couple.