Is GIFT (gamete intrafallopian transfer) the best treatment for unexplained infertility?
作者信息
Murdoch A P, Harris M, Mahroo M, Williams M, Dunlop W
机构信息
Northern Regional Fertility Centre, Department of Obstetrics and Gynaecology, Royal Victoria Infirmary, Newcastle upon Tyne.
出版信息
Br J Obstet Gynaecol. 1991 Jul;98(7):643-7. doi: 10.1111/j.1471-0528.1991.tb13449.x.
OBJECTIVE
To compare the cumulative pregnancy rates after gamete intrafallopian transfer (GIFT) with the cumulative spontaneous pregnancy rates in couples with unexplained infertility.
DESIGN
A contemporaneous study in a single group of patients.
SETTING
Northern Regional Fertility Centre.
SUBJECTS
76 couples with unexplained infertility of more than 3 years duration.
INTERVENTIONS
Successful pregnancies were recorded during at least 3 months before GIFT and up to 21 months after a maximum of three cycles of GIFT treatment.
MAIN OUTCOME MEASURES
Pregnancy resulting in a live birth.
RESULTS
Average monthly fecundability without treatment was 0.021 and after GIFT was 0.14 (P less than 0.001). This was reflected as a cumulative pregnancy rate of 52% after three cycles of GIFT and 30% after 24 months without treatment.
CONCLUSIONS
The chance of having a baby after one cycle of GIFT is significantly greater than the chance in a spontaneous cycle. However, considering the cumulative pregnancy rates, we suggest that if GIFT is to be a realistic treatment option, it should be offered for more than one cycle.
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