Kisara K, Sakurada S, Tadano T, Sakurada T, Tan-No K, Usui C, Kitano Y, Takasuna K
Department of Pharmacology, Tohoku College of Pharmacy, Sendai, Japan.
Nihon Yakurigaku Zasshi. 1993 Apr;101(4):269-80. doi: 10.1254/fpj.101.4_269.
Central effects of intravenously (i.v.)-administered iohexol were compared with those of iopamidol in a series of tests. Mannitol was used as a reference. As assayed by the primary screening test based on Irwin's method, i.v. administration of mannitol resulted in a score of 0 in ddY mice and a score of 0.6 in ICR mice in the startle response. These results were not different from the data of both iohexol and iopamidol. Iopamidol at a dose of 1750 mgI/kg produced an inhibitory effect on the spontaneous locomotor activity. Iohexol at a dose of 7000 mgI/kg potentiated the duration of thiopental-induced narcosis. Hypothermia was caused by high doses of both iohexol and iopamidol. Electric stimulus increased the mortality of mice pretreated with high doses of iohexol and iopamidol. Both drugs had no notable activities in the anticonvulsant, electroencephalic, muscle relaxant and antinociceptive tests. These results indicate that both iohexol and iopamidol do not necessarily possess a similar pharmacological action. Judging from the LD50 of approximately 15000 mgI/kg for both drugs, they seem unlikely to have a specific pharmacological action on the central nervous system.
在一系列试验中，比较了静脉注射碘海醇与碘帕醇的中枢效应。甘露醇用作对照。根据基于欧文方法的初筛试验测定，静脉注射甘露醇后，ddY小鼠的惊吓反应评分为0，ICR小鼠为0.6。这些结果与碘海醇和碘帕醇的数据无差异。剂量为1750mgI/kg的碘帕醇对自发运动活性产生抑制作用。剂量为7000mgI/kg的碘海醇可延长硫喷妥钠诱导的麻醉持续时间。高剂量的碘海醇和碘帕醇均导致体温过低。电刺激增加了高剂量碘海醇和碘帕醇预处理小鼠的死亡率。两种药物在抗惊厥、脑电图、肌肉松弛和镇痛试验中均无显著活性。这些结果表明，碘海醇和碘帕醇不一定具有相似的药理作用。从两种药物约15000mgI/kg的半数致死量判断，它们似乎不太可能对中枢神经系统有特异性药理作用。
