Chandler J A, Timms B G, Morton M S
Histochem J. 1977 Jan;9(1):103-20. doi: 10.1007/BF01007013.
Zinc is distributed subcellularly throughout the lateral prostate of the rat in both the stromal and epithelial elements. The connective tissue appears to be a major store of zinc. Within the epithelium, the highest concentrations of the element are found in the lysosomes, nucleoli, nuclear chromatin, secretory granules and luminal secretion. Histochemical studies indicate that the metal is bound relatively tightly within the nucleoli (associated with RNA) and in the secretory products of the cytoplasm. Changes in tissue zinc concentration, observed by other workers, following changes in various external stimuli, may not necessarily be reflected by proportionate changes in epithelial concentrations. The role of zinc in the epithelium is considered to be at least two-fold: firstly, for incorporation into vital cellular mechanisms necessary for cell maintenance and, secondly, for involvement in secretory products. It is also possible that the metal participates in the physiology of the sub-epithelial stroma.
锌在大鼠前列腺外侧的基质和上皮细胞中呈亚细胞分布。结缔组织似乎是锌的主要储存部位。在上皮细胞内，该元素的最高浓度出现在溶酶体、核仁、核染色质、分泌颗粒和管腔分泌物中。组织化学研究表明，金属在核仁内（与RNA相关）和细胞质的分泌产物中结合相对紧密。其他研究人员观察到，在各种外部刺激发生变化后，组织锌浓度的变化不一定会反映在上皮细胞浓度的相应变化中。锌在上皮细胞中的作用至少有两个方面：第一，用于纳入维持细胞所需的重要细胞机制；第二，参与分泌产物的形成。金属也有可能参与上皮下基质的生理过程。
