Mokhtar N, Rousseau-Migneron S, Tancrède G, Nadeau A
Diabetes Research Unit, Université Laval, Laval University Medical Center, Ste-Foy, Quebec, Canada.
J Appl Physiol (1985). 1993 Apr;74(4):1785-90. doi: 10.1152/jappl.1993.74.4.1785.
This study was designed to assess the effect of physical training on high-energy phosphate levels in the heart of diabetic rats. Diabetes was induced with streptozocin (50 mg/kg), and exercise training was carried out on a treadmill with a progressive 10-wk program. Plasma glucose levels at the end of the training program showed only a small improvement of the diabetic state in trained animals (21.7 +/- 1.3 vs. 24.4 +/- 0.8 mmol/l; P < 0.05). The lower heart rate observed in sedentary diabetic rats (279 +/- 6 vs. 356 +/- 5 beats/min; P < 0.001) was improved by physical training (301 +/- 8 beats/min; P < 0.05 vs. sedentary diabetics). Significantly lower phosphocreatine levels were found in sedentary diabetic rats (12.0 +/- 0.7 mumol/g dry wt) than in sedentary control rats (15.0 +/- 0.9 mumol/g dry wt; P < 0.05) but not in trained diabetic rats (13.7 +/- 0.7 mumol/g dry wt). ATP levels were not affected by diabetes but were increased by training. The increased long-chain acyl-CoA levels in sedentary diabetic rats (146 +/- 7 vs. 119 +/- 8 mumol/g dry wt in sedentary control rats; P < 0.05) were improved by training (138 +/- 6 mumol/g dry wt; P > 0.05 vs. sedentary control rats). These data indicate that the diminution in phosphocreatine levels observed in the heart tissue of chronically diabetic rats can be attenuated by an exercise training program.
本研究旨在评估体育锻炼对糖尿病大鼠心脏中高能磷酸水平的影响。用链脲佐菌素（50mg/kg）诱导糖尿病，通过一个为期10周的递增方案在跑步机上进行运动训练。训练方案结束时，训练组动物的血浆葡萄糖水平仅显示糖尿病状态有小幅改善（21.7±1.3与24.4±0.8mmol/L；P<0.05）。久坐的糖尿病大鼠心率较低（279±6与356±5次/分钟；P<0.001），体育锻炼使其得到改善（301±8次/分钟；与久坐的糖尿病大鼠相比，P<0.05）。久坐的糖尿病大鼠磷酸肌酸水平（12.0±0.7μmol/g干重）显著低于久坐的对照大鼠（15.0±0.9μmol/g干重；P<0.05），但训练的糖尿病大鼠中未出现这种情况（13.7±0.7μmol/g干重）。ATP水平不受糖尿病影响，但训练可使其升高。久坐的糖尿病大鼠中长链酰基辅酶A水平升高（146±7与久坐对照大鼠的119±8μmol/g干重；P<0.05），训练使其得到改善（138±6μmol/g干重；与久坐对照大鼠相比，P>0.05）。这些数据表明，慢性糖尿病大鼠心脏组织中观察到的磷酸肌酸水平降低可通过运动训练方案得到缓解。
