Massingale T W, Buttross S
Child Development Clinic, Children's Hospital, University of Mississippi Medical Center, Jackson 39216.
J Perinatol. 1993 Mar-Apr;13(2):107-10.
A nationwide survey of neonatologists was conducted to determine the common management of neonatal seizures. The questionnaire addressed practice setting, causes, length of treatment, and criteria used in discontinuation of treatment. A response rate of 68% was achieved. Results indicate continued disagreement among practitioners. The prevailing literature recommends treatment of neonatal seizures in the acute phase. Recent studies indicate that 8% to 15% of infants with neonatal seizures will have recurrent seizures after the newborn period. Animal models have shown that brain growth retardation and behavioral and learning impairment may occur from the use of phenobarbital in early infancy. The question of continued treatment of neonatal seizures beyond the acute phase is raised.
开展了一项针对新生儿科医生的全国性调查，以确定新生儿惊厥的常见处理方法。调查问卷涉及执业环境、病因、治疗时长以及停药标准。问卷回复率为68%。结果表明，从业者之间仍存在分歧。主流文献建议在急性期治疗新生儿惊厥。近期研究表明，8%至15%的新生儿惊厥患儿在新生儿期过后会出现反复惊厥。动物模型显示，婴儿早期使用苯巴比妥可能会导致脑发育迟缓以及行为和学习障碍。由此引发了关于新生儿惊厥急性期过后是否继续治疗的问题。
