基于结构的嘌呤核苷磷酸化酶抑制剂的设计。2. 9-脱氮鸟嘌呤的9-脂环族和9-杂脂环族衍生物。
Structure-based design of inhibitors of purine nucleoside phosphorylase. 2. 9-Alicyclic and 9-heteroalicyclic derivatives of 9-deazaguanine.
作者信息
Secrist J A, Niwas S, Rose J D, Babu Y S, Bugg C E, Erion M D, Guida W C, Ealick S E, Montgomery J A
机构信息
BioCryst Pharmaceuticals, Inc., Birmingham, Alabama 35244.
出版信息
J Med Chem. 1993 Jun 25;36(13):1847-54. doi: 10.1021/jm00065a007.
PMID:8515423
Abstract
Alicyclic and heteroalicyclic derivatives of 9-deazaguanine (2-amino-1,5-dihydro-4H-pyrrolo[3,2-d] [pyrimidin-4-one) are, with one exception, potent inhibitors of purine nucleoside phosphorylase (PNP) equaling the corresponding 9-arylmethyl derivatives previously investigated. The mode of binding of these compounds to PNP was determined by X-ray crystallography.
摘要
9-脱氮鸟嘌呤（2-氨基-1,5-二氢-4H-吡咯并[3,2-d][嘧啶-4-酮]）的脂环族和杂脂环族衍生物，除了一个例外，都是嘌呤核苷磷酸化酶（PNP）的强效抑制剂，与先前研究的相应9-芳基甲基衍生物相当。通过X射线晶体学确定了这些化合物与PNP的结合模式。
Zotero 插件