Furukawa T, Shimizu C, Uji T, Miyake Y, Hyodo A, Deguchi K
Anticancer and Antimicrobial Research Lab., Taiho Pharmaceutical Co., Ltd.
Jpn J Antibiot. 1993 Apr;46(4):310-7.
The in vivo synergistic effect of cefodizime (CDZM) in combination with minocycline (MINO) against methicillin-resistant Staphylococcus aureus (MRSA) was investigated. A study of fractional effective dose (FED) index showed that either synergistic or additive effect was observed between CDZM and MINO. The postantibiotic effect (PAE) of MINO was not altered by the addition of CDZM. However, a strong synergistic bactericidal effect of CDZM and MINO against MRSA CT-18 was observed for more than 14 hours in the presence of immunocompromised tumour bearing murine polymorphonuclear leukocytes (PMN). These results suggest that the strong therapeutic efficacy of CDZM in combination with MINO was caused by synergistic bactericidal effect of the 2 drugs in the presence of PMN.
研究了头孢地嗪（CDZM）与米诺环素（MINO）联合对耐甲氧西林金黄色葡萄球菌（MRSA）的体内协同作用。部分有效剂量（FED）指数研究表明，CDZM和MINO之间观察到协同或相加作用。添加CDZM不会改变MINO的抗生素后效应（PAE）。然而，在免疫功能低下的荷瘤小鼠多形核白细胞（PMN）存在的情况下，观察到CDZM和MINO对MRSA CT-18有超过14小时的强协同杀菌作用。这些结果表明，CDZM与MINO联合使用的强大治疗效果是由两种药物在PMN存在下的协同杀菌作用引起的。
