Giroud J P, Fontagne J, Blondelon D, Adolphe M, Dunn C J
Biomedicine. 1977 Jan 31;27(1):19-22.
Acute non immunological inflammatory pleural exudates provoked by four different irritants and collected 4 hours later have been shown to be capable of stimulating DNA synthesis, in rat peritoneal macrophages in culture. It is postulated that a mitogenic factor, "Inflammatory Mitogenic Factor for Macrophages" IMF (M), could be responsible for this phenomenon. There may be a correlation between the protein concentration of the exudates and its mitogenic activity.
由四种不同刺激物引发并在4小时后收集的急性非免疫性炎性胸腔积液，已被证明能够刺激培养中的大鼠腹膜巨噬细胞进行DNA合成。据推测，一种促有丝分裂因子，即“巨噬细胞炎性促有丝分裂因子”（IMF）（M），可能是导致这种现象的原因。渗出液的蛋白质浓度与其促有丝分裂活性之间可能存在关联。
