Guarino M, Tricomi P, Cristofori E
Department of anatomical pathology, Hospital of Treviglio (Bergamo), Italy.
Pathologica. 1993 Jan-Feb;85(1095):123-7.
Collagenous spherulosis of the breast is a recently described lesion that was previously been seen only in a setting of benign, typical epitheliosis. We report that unusual case of a collagenous spherulosis of the breast in association with severely atypical epithelial hyperplasia in a 45-year-old woman. The patient presented an asymptomatic right lump and underwent a wide breast tissue resection. After a postoperative follow-up of twelve months, the patient remained well with no breast symptoms. Since atypical hyperplasia in the breast is considered predictive of relatively high risk of later carcinoma development, the finding of collagenous spherulosis with atypical hyperplasia should suggest a long-term follow-up. although at present the biological and prognostic significance of this association is unknown.
乳腺胶原球病是一种最近才被描述的病变，以前仅在良性、典型上皮增生的情况下出现。我们报告了一例45岁女性乳腺胶原球病合并严重非典型上皮增生的罕见病例。患者出现无症状的右侧肿块，接受了广泛的乳腺组织切除术。术后随访12个月，患者情况良好，无乳腺症状。由于乳腺非典型增生被认为预示着后期发生癌变的风险相对较高，因此发现胶原球病合并非典型增生应提示进行长期随访。尽管目前这种关联的生物学和预后意义尚不清楚。
