超氧化物歧化酶与肺氧中毒

Superoxide dismutase and pulmonary oxygen toxicity.

作者信息

Tsan M F

机构信息

Research Service, Samuel S. Stratton Department of Veterans Affairs Medical Center, Albany, New York 12208.

出版信息

Proc Soc Exp Biol Med. 1993 Jul;203(3):286-90. doi: 10.3181/00379727-203-43600a.

DOI:10.3181/00379727-203-43600a

PMID:8516341

Abstract

Three forms of superoxide dismutase (SOD) exist in the lung: CuZnSOD, MnSOD and extracellular SOD. Evidence suggests that both CuZnSOD and MnSOD are important in pulmonary defense against oxygen toxicity. Enhancement of pulmonary levels of CuZnSOD by transgenic overexpression of CuZnSOD, or tracheal insufflation of liposome-encapsulated or polyethylene glycol-conjugated CuZnSOD, protects animals against oxygen toxicity. Likewise, transgenic overexpression of MnSOD, or induction of endogenous MnSOD by endotoxin, tumor necrosis factor, or interleukin 1, also protects animals against oxygen toxicity. The role of extracellular SOD in the pulmonary defense against oxygen toxicity is not clear.

摘要

肺中存在三种形式的超氧化物歧化酶（SOD）：铜锌超氧化物歧化酶（CuZnSOD）、锰超氧化物歧化酶（MnSOD）和细胞外超氧化物歧化酶。有证据表明，CuZnSOD和MnSOD在肺部抵御氧毒性方面都很重要。通过转基因过表达CuZnSOD或气管注入脂质体包裹或聚乙二醇偶联的CuZnSOD来提高肺部CuZnSOD水平，可保护动物免受氧毒性。同样，MnSOD的转基因过表达，或通过内毒素、肿瘤坏死因子或白细胞介素1诱导内源性MnSOD，也可保护动物免受氧毒性。细胞外超氧化物歧化酶在肺部抵御氧毒性中的作用尚不清楚。