Kanchurin A Kh, Babakhin A A, Safronova A V
Biull Eksp Biol Med. 1977 Mar;83(3):320-4.
Stable leukocytosis and lymphocytosis were observed in the peripheral blood of guinea pigs from the 14th day after their sensitization with B. pertussis oil suspension. A shift to the left occurred in the leukocytic count. After the contact of leukocytes with the specific cerebral antigen both in vivo and in vitro leukolysis and allergic alteration of leukocytes which occurred at the last stages of sensitization i.e. at the period of clinical manifestation of the experimental allergic encephalomyelitis (EAE) involved mainly the granulocytes. These phenomena are supposed to be caused by the anticerebral antibodies which appear in the blood at this stage of EAE, i.e. in the mechanism of development of EAE allergic reactions of the immediate type in combination with allergic reactions of the delayed type.
在用百日咳杆菌油悬液致敏豚鼠后的第14天，在其外周血中观察到稳定的白细胞增多和淋巴细胞增多。白细胞计数出现左移。在体内和体外，白细胞与特异性脑抗原接触后，在致敏的最后阶段，即在实验性变应性脑脊髓炎（EAE）临床表现期发生的白细胞溶解和白细胞的变态反应性改变主要涉及粒细胞。这些现象被认为是由在EAE这个阶段血液中出现的抗脑抗体引起的，即在EAE发生机制中，速发型变态反应与迟发型变态反应相结合。
