Melville L D, Smith G P, Gibbs J
Department of Psychiatry, Cornell University Medical College, White Plains, NY.
Pharmacol Biochem Behav. 1993 May;45(1):85-7. doi: 10.1016/0091-3057(93)90090-g.
We investigated the satiating potency of CCK-33 and of CCK-8 administered IP to rats prior to a 30-min food intake test using a high-carbohydrate liquid diet. CCK-33 and CCK-8 produced dose-related inhibitions of intake. The ID50S and the slopes of the dose-response functions of the two peptides were not significantly different. We conclude that CCK-33 is as potent as CCK-8 for inhibiting food intake in the rat.
我们在大鼠进行30分钟高碳水化合物液体饮食摄入测试前，通过腹腔注射研究了CCK - 33和CCK - 8的饱腹感效力。CCK - 33和CCK - 8均产生了与剂量相关的摄入抑制作用。两种肽的半数抑制剂量（ID50）和剂量反应函数的斜率无显著差异。我们得出结论，在抑制大鼠食物摄入方面，CCK - 33与CCK - 8的效力相当。
