Ohno M, Yamamoto T, Watanabe S
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan.
Pharmacol Biochem Behav. 1993 May;45(1):89-93. doi: 10.1016/0091-3057(93)90091-7.
In a three-panel runway task, intrahippocampal injection of the nicotinic receptor antagonist, mecamylamine (10 and 18 micrograms/side), significantly increased the number of errors (attempts to pass through two incorrect panels of the three panel-gates at four choice points) in a test of working memory. This increase in errors also occurred after rats were given IP mecamylamine (10 mg/kg). Mecamylamine did not affect the number of errors in a test of reference memory whether it was given at doses up to 18 micrograms/side intrahippocampally or up to 10 mg/kg IP. These results suggest that mechanisms mediated by hippocampal nicotinic receptors play a role in working memory but not in reference memory.
在一项三面板跑道任务中，向海马体内注射烟碱样受体拮抗剂美加明（每侧10微克和18微克），在工作记忆测试中显著增加了错误数量（在四个选择点尝试穿过三面板门中两个不正确面板的次数）。给大鼠腹腔注射美加明（10毫克/千克）后也出现了错误数量增加的情况。无论海马体内注射剂量高达每侧18微克还是腹腔注射剂量高达10毫克/千克，美加明都不影响参考记忆测试中的错误数量。这些结果表明，海马烟碱样受体介导的机制在工作记忆中起作用，但在参考记忆中不起作用。
