Volf N V, Senkova N I, Danilenko K V, Putilov A A
Novosibirsk State University, Russia.
Psychiatry Res. 1993 Apr;47(1):99-108. doi: 10.1016/0165-1781(93)90059-p.
Thirty-seven patients with seasonal affective disorder (SAD) and 25 control subjects were given a concurrent task, the verbal-manual interference paradigm, as a measure of hemispheric language lateralization. In winter, depressed patients showed a symmetrical interference pattern and control subjects experienced greater overall disruption in right-hand tapping during concurrent verbalization. Patients showed a greater left-hand tapping decrement compared with control subjects. Light treatment decreased the decrement in tapping with the left but not with the right hand in patients. After treatment, patients did not differ from controls in dual task interference effects. Patients also showed no difference from controls in summer. The difference between depressed subjects and controls in performance measures of laterality suggests that winter depression is associated with a shift of laterality from the left to the right. The winter abnormalities appear to be normalized by bright light.
37名季节性情感障碍（SAD）患者和25名对照受试者接受了一项并行任务，即言语-手动干扰范式，作为半球语言侧化的一种测量方法。在冬季，抑郁患者表现出对称的干扰模式，而对照受试者在同时进行言语表达时右手敲击受到的总体干扰更大。与对照受试者相比，患者左手敲击的减少幅度更大。光照治疗减少了患者左手敲击的减少幅度，但右手没有。治疗后，患者在双重任务干扰效应方面与对照受试者没有差异。患者在夏季与对照受试者也没有差异。抑郁受试者和对照受试者在侧化表现测量上的差异表明，冬季抑郁与侧化从左侧向右侧的转变有关。冬季的异常情况似乎通过强光得到了正常化。
