Andersson A
Lancet. 1979 Mar 17;1(8116):581-4. doi: 10.1016/s0140-6736(79)91008-0.
Islet-cell deterioration in juvenile diabetes mellitus may be due to an autoimmune reaction, possibly involving both circulating islet-cell antibodies and an inflammatory process in the islets of Langerhans. Replacement of deteriorated islet cells by implantation of normal ones is now under investigation in many laboratories. The present study does not support the assumption that such islet transplants should be affected in the same way as the endogenous islets. Diabetic mice with a cell-mediated immune reaction to their pancreatic islets, induced by repeated injections of low doses of streptozotocin, were used as recipients. Isogeneic islets implanted intrasplenically in these animals were as effective in producing normoglycaemia as were those injected into animals made diabetic with a single bolus dose of streptozotocin. No inflammatory reaction was seen in the implanted islets, irrespective of the regimen of the preceding streptozotocin treatment. This finding suggests that islet-cell implantation may be attempted in insulin-requiring diabetic patients, even if the cause of the disorder is an inflammatory lesion of the patient's own islets.
青少年糖尿病中的胰岛细胞退化可能是由于自身免疫反应，这可能涉及循环胰岛细胞抗体以及胰岛内的炎症过程。目前许多实验室正在研究通过植入正常胰岛细胞来替代退化的胰岛细胞。本研究不支持这样一种假设，即此类胰岛移植会与内源性胰岛受到相同方式的影响。通过重复注射低剂量链脲佐菌素诱导对其胰腺胰岛产生细胞介导免疫反应的糖尿病小鼠被用作受体。将同基因胰岛脾内植入这些动物，其产生正常血糖的效果与将胰岛注射到单次大剂量链脲佐菌素致糖尿病的动物体内相同。无论之前链脲佐菌素治疗的方案如何，植入的胰岛均未观察到炎症反应。这一发现表明，即使疾病的病因是患者自身胰岛的炎症性病变，也可以尝试对需要胰岛素的糖尿病患者进行胰岛细胞植入。
