Codde J P, Lumsden A J, Napoli S, Burton M A, Gray B N
University Department of Surgery, Royal Perth Hospital, Western Australia.
Anticancer Res. 1993 Mar-Apr;13(2):539-43.
Due to low efficacy of chemotherapy in the treatment of liver cancer, several methods of drug targeting have been investigated. Liposomes designed to carry cytotoxic drugs to the liver are currently under clinical evaluation. While experimental evidence shows promise, this method of drug delivery has several disadvantages that include short shelf life and poor drug delivery into tumour tissue. An alternative strategy for targeted drug delivery involving use of ion exchange microspheres may overcome these limitations while still reducing systemic toxicity and maintaining therapeutic efficacy. The purpose of this study was to determine the relative antitumour efficacy of these two drugs carrying systems in the treatment of liver cancer. Compared to controls, DOX treatment with free drug, liposomes or microspheres significantly reduced tumour growth by 56% (P < 0.001), 51% (P < 0.01) and 79% (P < 0.001) respectively. Furthermore, the DOX-microsphere treatment was significantly better than either of the other DOX treatments (53%, P < 0.05) or the sham-microsphere treated group (64%, P < 0.05). Thus, drug microspheres can increase the anti-tumour efficacy compared to either free or liposomal drug while simultaneously reducing systemic toxicity.
由于化疗在肝癌治疗中的疗效较低，人们已经研究了几种药物靶向方法。目前，旨在将细胞毒性药物输送到肝脏的脂质体正在进行临床评估。虽然实验证据显示出了前景，但这种药物递送方法存在几个缺点，包括保质期短和药物向肿瘤组织的递送效果不佳。一种涉及使用离子交换微球的靶向药物递送替代策略可能会克服这些局限性，同时仍能降低全身毒性并维持治疗效果。本研究的目的是确定这两种载药系统在肝癌治疗中的相对抗肿瘤疗效。与对照组相比，用游离药物、脂质体或微球进行阿霉素治疗分别使肿瘤生长显著降低了56%（P < 0.001）、51%（P < 0.01）和79%（P < 0.001）。此外，阿霉素-微球治疗明显优于其他两种阿霉素治疗（53%，P < 0.05）或假微球治疗组（64%，P < 0.05）。因此，与游离药物或脂质体药物相比，药物微球可以提高抗肿瘤疗效，同时降低全身毒性。
