Morgan M, Downs K, Chesterman C N, Biggs J C
Haematology Department, St Vincent's Hospital, Sydney, NSW.
Aust N Z J Med. 1993 Apr;23(2):151-6. doi: 10.1111/j.1445-5994.1993.tb01809.x.
A retrospective analysis of 125 consecutive lupus anticoagulant (LA) positive patients and 125 age, sex matched lupus anticoagulant negative controls is reported with the aims of defining further the clinical spectrum of disease, determining at-risk subgroups and management strategies. There was no significant difference in the incidence or pattern of complications in those with systemic lupus erythematosus (SLE) and related disorders, and those without SLE. Venous thromboembolism, immune thrombocytopenia, foetal loss, depression and hypertension were statistically more common in the LA group than in the control group. In contrast to previous reports, children aged ten years or less with the LA developed significantly more complications than controls. Patients with the LA secondary to drugs also developed complications, a finding which is also at variance with previous reports. There was a significant difference in the outcome of arterial disease (p < 0.04) and venous thromboembolism (p < 0.001) when long term anticoagulation was part of the treatment regimen.
报告了对125例连续的狼疮抗凝物（LA）阳性患者以及125例年龄、性别相匹配的LA阴性对照者的回顾性分析，目的是进一步明确疾病的临床谱、确定高危亚组以及管理策略。系统性红斑狼疮（SLE）及相关疾病患者与无SLE患者在并发症的发生率或类型方面无显著差异。静脉血栓栓塞、免疫性血小板减少症、胎儿丢失、抑郁和高血压在LA组中比对照组在统计学上更为常见。与既往报告相反，10岁及以下的LA患儿发生的并发症明显多于对照组。药物继发LA的患者也出现了并发症，这一发现也与既往报告不同。当长期抗凝作为治疗方案的一部分时，动脉疾病（p < 0.04）和静脉血栓栓塞（p < 0.001）的结局存在显著差异。
