Eneroth-Grimfors E, Lindblad L E, Westgren M, Ihrman-Sandahl C, Bevegård S
Department of Obstetrics and Gynaecology, Södersjukhuset, Stockholm, Sweden.
Br J Obstet Gynaecol. 1993 May;100(5):469-71. doi: 10.1111/j.1471-0528.1993.tb15274.x.
To examine microvascular endothelial cell function in vivo in pre-eclampsia.
Iontophoresis of acetylcholine (Ach), which gives rise to endothelial cell dependent vasodilatation, and of sodium nitroprusside (SNP), which elicits vasodilatation independently of functioning vascular endothelium.
Södersjukhuset, Stockholm, Sweden.
Ten pre-eclamptic patients, ten healthy pregnant women and ten healthy nonpregnant women were examined.
The degree of vasodilatation following iontophoretic administration of Ach compared with SNP was recorded with a laser Doppler technique, the data being analysed on a personal computer.
Both Ach and SNP administration resulted in marked vasodilatation; the magnitude of the vasodilatation was similar in the three groups of women.
Following iontophoretic administration of endothelial cell dependent or independent vasodilatators, laser Doppler measurement of blood flow demonstrated no microvascular endothelial cell dysfunction in pre-eclamptic women.
研究子痫前期患者体内微血管内皮细胞功能。
采用乙酰胆碱（Ach）离子导入法，其可引起内皮细胞依赖性血管舒张；以及硝普钠（SNP）离子导入法，其可独立于功能性血管内皮引起血管舒张。
瑞典斯德哥尔摩南医院。
对10例子痫前期患者、10例健康孕妇和10例健康非孕妇进行了检查。
采用激光多普勒技术记录离子导入Ach与SNP后血管舒张程度，并在个人电脑上对数据进行分析。
给予Ach和SNP均导致明显的血管舒张；三组女性的血管舒张程度相似。
离子导入内皮细胞依赖性或非依赖性血管舒张剂后，激光多普勒血流测量显示子痫前期女性无微血管内皮细胞功能障碍。
