Oliván Martínez J, Hoyos Jiménez M, Miranda García M J, Justo Alpañés E, Pérez Cano R
Departamento de Medicina Interna, Hospital Universitario Virgen Macarena, Sevilla.
An Med Interna. 1993 May;10(5):221-7.
We tried to assess the antihypertensive effectivity of a betablocker, celiprolol, in the control of mild to moderate essential arterial hypertension. A double-blind randomized comparative study was conducted between celiprolol and amiloride-hydrochlorothiazide in 40 patients with mild to moderate essential hypertension. Both drugs were effective in the therapeutical control of hypertension, although reductions in systolic blood pressure were more significant among the celiprolol group, being the percentage of patients with reduction of diastolic blood pressure below 90 mmHg., 89.5% in the celiprolol group and 82.4% in the amiloride group. The average dose of celiprolol used was 200 mg/day, with few mide effects.
我们试图评估β受体阻滞剂塞利洛尔在控制轻至中度原发性动脉高血压方面的降压有效性。对40例轻至中度原发性高血压患者进行了塞利洛尔与阿米洛利 - 氢氯噻嗪的双盲随机对照研究。两种药物在高血压治疗控制方面均有效，尽管收缩压降低在塞利洛尔组中更为显著，舒张压降低至90 mmHg以下的患者百分比，塞利洛尔组为89.5%，阿米洛利组为82.4%。所用塞利洛尔的平均剂量为200毫克/天，副作用较少。
