Kapoor R, Smith K J, Felts P A, Davies M
University Department of Clinical Neurology, Institute of Neurology, Queen Square, London, UK.
Brain Res. 1993 May 14;611(1):165-9. doi: 10.1016/0006-8993(93)91790-y.
Positive clinical symptoms can arise from ectopic action potentials in several disorders of myelinated axons. Here we report that an elevated K+ concentration in the periaxonal, internodal space can cause internodal K+ currents to become excitatory, resulting in slow potential oscillations and associated bursts of ectopic spikes. Ectopic firing may therefore be favoured by conditions in which periaxonal K+ buffering is compromised.
