Riepl R L, Schreiner J, Müller B, Hildemann S, Loeschke K
Medizinische Klinik, Universität München.
Dtsch Med Wochenschr. 1993 Jun 25;118(25):932-5. doi: 10.1055/s-2008-1059408.
A previously healthy 17-year-old Greek boy suddenly developed jaundice of sclerae and skin. In addition, physical examination revealed a pale appearance. He also reported feeling tired and weak. The haemoglobin level was 9.6 g/dl, lactate dehydrogenase activity 335 U/l, bilirubin concentration 3.2 mg/dl (direct bilirubin 0.7 mg/dl, indirect bilirubin 2.5 mg/dl), haptoglobin concentration 48.8 mg/dl. As haemolytic anaemia was assumed, direct questioning elicited the fact that the patient had, for the first time in his life, eaten 300 g of broad beans (Vicia faba) on each of two days, namely 3 and 2 days before the appearance of jaundice. Absence of glucose-6-phosphate dehydrogenase activity in the red blood corpuscles confirmed the diagnosis of favism. On symptomatic treatment both the enzyme activities and the bilirubin level fell to normal within one week, and the haemoglobin level was 15.7 g/dl after 4 weeks.
一名既往健康的17岁希腊男孩突然出现巩膜和皮肤黄疸。此外，体格检查发现其面色苍白。他还自述感到疲倦和虚弱。血红蛋白水平为9.6 g/dl，乳酸脱氢酶活性为335 U/l，胆红素浓度为3.2 mg/dl（直接胆红素0.7 mg/dl，间接胆红素2.5 mg/dl），触珠蛋白浓度为48.8 mg/dl。由于怀疑为溶血性贫血，经直接询问得知，该患者在黄疸出现前3天和2天，生平第一次连续两天每天食用了300克蚕豆（蚕豆属）。红细胞中葡萄糖-6-磷酸脱氢酶活性缺乏确诊为蚕豆病。经对症治疗，酶活性和胆红素水平在一周内降至正常，4周后血红蛋白水平为15.7 g/dl。
