Le Scao Y, Jezequel J, Robier A, Baulieu J L, Turzo A, Guias B, Morin P P
Department of Nuclear Medicine, CHU Morvan, Brest, France.
Eur J Nucl Med. 1993 May;20(5):387-90. doi: 10.1007/BF00208996.
Development of auditory stimulation tests associated with single-photon emission tomography (SPET) shows evidence of variations in perfusion related to the stimuli. Three brain SPET examinations with technetium-99m hexamethylpropylene amine oxime were performed on eight right-handed adults with normal hearing, the first one without stimulation and the other two associated with a 500-Hz/30-dB stimulation of the right ear. Temporal regions of interest covering auditory areas, as well as parietal ones (internal control), were drawn on three successive coronal slices. A cortico-cerebellar index R was calculated, and the variation in activity was defined for each subject using the ratio R poststimulation--R prestimulation/R prestimulation. A significant increase in the temporal cortex count occurred in all subjects. This increase was bilateral, except for one subject in whom it was not significant on the right side. This result recurred during the second stimulation study. Overall the response of the left temporal cortex was stronger, although the asymmetry was not significant. The asymmetry repeated itself after each stimulation. The perfusion response is globally reliable in our study. We must ascertain how sensitive this test is with regard to deaf adults and adults with normal hearing before extending its use to children.
与单光子发射断层扫描（SPET）相关的听觉刺激测试的发展显示出与刺激相关的灌注变化的证据。对八名听力正常的右利手成年人进行了三次使用锝-99m六甲基丙烯胺肟的脑部SPET检查，第一次无刺激，另外两次与右耳500赫兹/30分贝的刺激相关。在三个连续的冠状切片上绘制了覆盖听觉区域以及顶叶区域（内部对照）的颞部感兴趣区。计算了皮质-小脑指数R，并使用刺激后R - 刺激前R/刺激前R的比值为每个受试者定义了活动变化。所有受试者的颞叶皮质计数均显著增加。这种增加是双侧性的，但有一名受试者右侧不显著。在第二次刺激研究中再次出现了这一结果。总体而言，左侧颞叶皮质的反应更强，尽管不对称性不显著。每次刺激后不对称性都会重复出现。在我们的研究中，灌注反应总体上是可靠的。在将其应用扩展到儿童之前，我们必须确定该测试对成年聋人和听力正常的成年人的敏感性如何。
