Chakrabarti A, Chugh Y, Sharma P L
Department of Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Eur J Pharmacol. 1993 Apr 22;235(1):133-6. doi: 10.1016/0014-2999(93)90832-3.
Diazepam (10 mg/kg i.p.) or MK-801 (0.25 mg/kg i.p.) offered complete protection against corneal electroshock (30 mA x 0.2 s)-induced tonic seizures and lethality but failed to protect from aminophylline (150 mg/kg i.p.) + electroshock (15 mA x 0.2 s)-induced tonic seizures and lethality in mice. The diazepam (2.5 mg/kg i.p.) and MK-801 (0.25 mg/kg i.p.) combination completely protected the mice from aminophylline + electroshock-induced seizures and lethality. Sodium valproate (500 mg/kg i.p.) protected the mice from electroshock (30 mA) per se and aminophylline + electroshock (15 mA)-induced seizure and lethality. The present study established the neurosensitizing potential of a single, non-convulsive dose of aminophylline for electroconvulsion due to subthreshold intensity electroshock and demonstrated the prophylactic efficacy of sodium valproate and the synergistic therapeutic potential of diazepam and MK-801 combination against such seizure attacks.
地西泮（腹腔注射10毫克/千克）或MK - 801（腹腔注射0.25毫克/千克）可完全保护小鼠免受角膜电休克（30毫安×0.2秒）诱发的强直性惊厥和致死作用，但不能保护小鼠免受氨茶碱（腹腔注射150毫克/千克）+电休克（15毫安×0.2秒）诱发的强直性惊厥和致死作用。地西泮（腹腔注射2.5毫克/千克）和MK - 801（腹腔注射0.25毫克/千克）联合用药可完全保护小鼠免受氨茶碱+电休克诱发的惊厥和致死作用。丙戊酸钠（腹腔注射500毫克/千克）可保护小鼠免受电休克（30毫安）本身以及氨茶碱+电休克（15毫安）诱发的惊厥和致死作用。本研究确定了单次非惊厥剂量的氨茶碱对阈下强度电休克所致惊厥的神经致敏潜力，并证明了丙戊酸钠的预防效果以及地西泮和MK - 801联合用药对此类惊厥发作的协同治疗潜力。
