Di Giorgio A, Botti C, Mingazzini P, Canavese A, Arnone P
Institute of Clinical Surgery, University of Rome, La Sapienza, Italy.
Eur J Surg. 1995 Aug;161(8):575-80.
To assess the prognostic value of various immunomorphological variables in the prognosis of gastric cancer after curative resection.
Retrospective study.
University hospital, Italy.
180 Patients who underwent curative resection for carcinoma of the distal two thirds of stomach between January 1960 and December 1978. Curative was defined as no residual cancer at the resection margins and no distant metastases.
All living patients were followed-up, and missing survival data were obtained from the Official Census Registry.
Correlation between survival and nuclear grade, lymphocytic infiltration, and types of lymph node reaction such as sinus histiocytosis, paracortical lymphoid cellular hyperplasia, and follicular hyperplasia in the cortical area.
Crude 5 year and 10 year survival rates were 46% and 36%, respectively. Sex, site, and histological type of the tumour did not correlate with survival. Multivariate analysis showed that only pTNM stage of disease and degree of sinus histiocytosis were significantly related to survival.
There may be an argument for using the presence or absence of sinus histiocytosis to stratify patients in prospective studies of adjuvant treatment.
评估各种免疫形态学变量在胃癌根治性切除术后预后中的价值。
回顾性研究。
意大利大学医院。
1960年1月至1978年12月期间因胃远端三分之二癌接受根治性切除的180例患者。根治定义为切除边缘无残留癌且无远处转移。
对所有在世患者进行随访，并从官方人口普查登记处获取缺失的生存数据。
生存与核分级、淋巴细胞浸润以及皮质区淋巴结反应类型（如窦组织细胞增生、副皮质区淋巴细胞增生和滤泡增生）之间的相关性。
5年和10年的粗生存率分别为46%和36%。肿瘤的性别、部位和组织学类型与生存无相关性。多变量分析显示，只有疾病的pTNM分期和窦组织细胞增生程度与生存显著相关。
在辅助治疗的前瞻性研究中，可能有理由根据窦组织细胞增生的有无对患者进行分层。
