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Direct enantiomeric separation of platelet-activating factor receptor antagonist SM-10661 by ligand-exchange high-performance liquid chromatography with a copper (II) N,S-dioctyl-D-penicillamine complex.

作者信息

Okamoto M, Ueda Y, Takahashi K, Nakazawa H, Doi T

机构信息

Environmental Health Science Laboratory, Sumitomo Chemical Co., Ltd., Osaka, Japan.

出版信息

Biosci Biotechnol Biochem. 1995 Sep;59(9):1740-1. doi: 10.1271/bbb.59.1740.

DOI:10.1271/bbb.59.1740
PMID:8520116
Abstract

The enantiomeric separation of SM-10661, a platelet activating factor receptor antagonist, was investigated by HPLC using ligand-exchange chiral stationary phases. The stereoisomers of SM-10661 could all be separated by ligand-exchange HPLC with a Cu(II) N,S-dioctyl-D-penicillamine complex (Sumichiral OA-5000). The mechanism for the resolution includes the involvement of hydrophobic interactions between SM-10661 and Cu(II) D-penicillamine.

摘要

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