近平滑假丝酵母中(S)-1,3-丁二醇脱氢酶的纯化与特性分析
Purification and characterization of (S)-1,3-butanediol dehydrogenase from Candida parapsilosis.
作者信息
Yamamoto H, Matsuyama A, Kobayashi Y, Kawada N
机构信息
Tsukuba Research Center, Daicel Chemical Industries, Ltd., Ibaraki, Japan.
出版信息
Biosci Biotechnol Biochem. 1995 Sep;59(9):1769-70. doi: 10.1271/bbb.59.1769.
PMID:8520120
Abstract
(S)-1,3-Butanediol (BDO) oxidizing enzyme was purified from Candida parapsilosis IFO 1396, which could produce (R)-1,3-BDO from the racemate. The purified enzyme was an NAD(+)-dependent secondary alcohol dehydrogenase that oxidized (S)-1,3-BDO to 4-hydroxy-2-butanone stereo-specifically.
摘要
从近平滑假丝酵母IFO 1396中纯化出了(S)-1,3-丁二醇（BDO）氧化酶，该酶可从外消旋体中产生(R)-1,3-BDO。纯化后的酶是一种依赖NAD(+)的仲醇脱氢酶，可将(S)-1,3-BDO立体特异性地氧化为4-羟基-2-丁酮。
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