Rommel O, Tegenthoff M, Pern U, Strumpf M, Zenz M, Malin J P
University Department of Clinical Neurology, Ruhr-University Bochum, BG-Kliniken Bergmannsheil, Germany.
Clin Auton Res. 1995 Sep;5(4):205-10. doi: 10.1007/BF01824008.
The sympathetic skin response (SSR) originates from synchronized activation of the sweat glands as a response to a volley discharge in efferent sympathetic nerve fibres. The aim of the study was to verify the diagnostic value of SSR in patients with reflex sympathetic dystrophy (RSD). SSR was recorded in 20 normal subjects and in 24 patients with predominantly chronic RSD. In normal subjects inter- and intra-individually different mono-, bi- and triphasic potentials could be recorded without difference of the waveform from side to side. SSR abnormalities were found in 15 patients and correlated with the severity of the disease. In patients with slight dystrophies, SSR was predominantly normal. In intermediate dystrophies, mainly differences of the SSR waveform between sides could be recorded, indicating unilateral sudomotor dysfunction. In severe dystrophies abnormalities of SSR amplitude or latency were found, indicating more serious disturbance of sudomotor activity, possibly due to a lesion of sympathetic fibres. The SSR provides useful information on sudomotor dysfunction in patients with RSD. However, as there is no consensus in the literature for the clinical criteria to diagnose RSD, it is not yet possible to determine the final diagnostic value of SSR for the diagnoses of RSD.
交感神经皮肤反应（SSR）源于汗腺的同步激活，这是对传出交感神经纤维的一连串放电的反应。本研究的目的是验证SSR在反射性交感神经营养不良（RSD）患者中的诊断价值。对20名正常受试者和24名以慢性RSD为主的患者进行了SSR记录。在正常受试者中，可记录到个体间和个体内不同的单相、双相和三相电位，两侧波形无差异。15例患者出现SSR异常，且与疾病严重程度相关。在轻度营养不良患者中，SSR大多正常。在中度营养不良患者中，主要可记录到两侧SSR波形的差异，提示单侧汗腺运动功能障碍。在重度营养不良患者中，发现SSR振幅或潜伏期异常，提示汗腺运动活动受到更严重的干扰，可能是由于交感神经纤维受损所致。SSR为RSD患者的汗腺运动功能障碍提供了有用信息。然而，由于文献中对于RSD的临床诊断标准尚无共识，目前尚无法确定SSR对RSD诊断的最终诊断价值。
