突触样微囊泡：它们参与调节性胞吐作用吗？

Synaptic like microvesicles: do they participate in regulated exocytosis?

作者信息

Llona I

机构信息

Facultad de Ciencias Medicas, Universidad de Santiago de Chile, Chile.

出版信息

Neurochem Int. 1995 Sep;27(3):219-26. doi: 10.1016/0197-0186(95)00005-s.

DOI:10.1016/0197-0186(95)00005-s

PMID:8520460

Abstract

Synaptic like microvesicles (SLMV) form a pleiomorphic population of vesicles present in neuroendocrine cells of the pituitary and the adrenal medulla. Their composition and biogenesis is very similar to small synaptic vesicles (SSV) present in nerve terminals. Membrane proteins of SSV involved in fusion (synaptotagmin) and trafficking (Rab 3) together with synaptophysin have been identified on SLMV. The SLMV from pancreatic beta cells store GABA, those present in chromaffin cells catecholamines and/or acetylcholine. We conclude that SLMV may participate in regulated exocytosis based on (a) their localization near release sites, (b) their content and (c) their membrane composition. The functional meaning and the way this process is regulated remain to be elucidated.

摘要

突触样微泡（SLMV）构成了存在于垂体和肾上腺髓质神经内分泌细胞中的多形性微泡群体。它们的组成和生物发生与神经末梢中的小突触小泡（SSV）非常相似。参与融合（突触结合蛋白）和运输（Rab 3）的SSV膜蛋白以及突触素已在SLMV上被鉴定出来。胰腺β细胞的SLMV储存γ-氨基丁酸（GABA），嗜铬细胞中的SLMV储存儿茶酚胺和/或乙酰胆碱。我们得出结论，基于以下几点，SLMV可能参与调节性胞吐作用：（a）它们在释放位点附近的定位；（b）它们的内容物；（c）它们的膜组成。这个过程的功能意义及其调节方式仍有待阐明。