Martins M C, Pileggi F, Maranhão R C
Instituto do Coração, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, Brasil.
Braz J Med Biol Res. 1995 Apr;28(4):427-31.
To determine whether the metabolism of chylomicrons and their remnants is related to atherogenesis, a triglyceride-rich emulsion known to mimic chylomicron behavior in plasma and labeled with 1-14C-cholesteryl oleate was injected intravenously into 11 normolipidemic patients (triglycerides: 133 +/- 60 mg/dl; total cholesterol: 207 +/- 20 mg/dl; LDL: 143 +/- 20 mg/dl; VLDL: 27 +/- 13 mg/dl; and HDL cholesterol: 41 +/- 11 mg/dl; apo AI: 1.27 +/- 0.54 g/l and apo B: 1.42 +/- 0.31 g/l) with atherosclerotic coronary artery disease and into 11 control subjects (triglycerides: 109 +/- 32 mg/dl; total cholesterol: 190 +/- 38 mg/dl; LDL: 125 +/- 29 mg/dl; VLDL: 22 +/- 6 mg/ dl; and HDL cholesterol: 44 +/- 9 mg/dl; apo AI: 1.09 +/- 0.28 g/l and apo B: 1.09 +/- 0.28 g/l) without the disease. The emulsion (69% triolein, 23% lecithin, 6% cholesteryl oleate and 2% cholesterol) was injected intravenously at approximately 9:00 a.m., after a 12-h fast. The clearance of the emulsion label from plasma, expressed as fractional clearance rate (FCR), was lower in coronary artery disease compared to controls (0.019 +/- 0.005/min vs 0.036 +/- 0.018/min, respectively, P < 0.05). These results indicate that the rate of removal of chylomicron remnants is slower in patients with coronary artery disease.
为了确定乳糜微粒及其残粒的代谢是否与动脉粥样硬化的发生有关，将一种富含甘油三酯的乳剂静脉注射到11名患有动脉粥样硬化性冠状动脉疾病的血脂正常患者（甘油三酯：133±60mg/dl；总胆固醇：207±20mg/dl；低密度脂蛋白：143±20mg/dl；极低密度脂蛋白：27±13mg/dl；高密度脂蛋白胆固醇：41±11mg/dl；载脂蛋白AI：1.27±0.54g/l和载脂蛋白B：1.42±0.31g/l）和11名无该疾病的对照受试者（甘油三酯：109±32mg/dl；总胆固醇：190±38mg/dl；低密度脂蛋白：125±29mg/dl；极低密度脂蛋白：22±6mg/dl；高密度脂蛋白胆固醇：44±9mg/dl；载脂蛋白AI：1.09±0.28g/l和载脂蛋白B：1.09±0.28g/l）体内。该乳剂（69%三油精、23%卵磷脂、6%油酸胆固醇和2%胆固醇）在禁食12小时后于上午9:00左右静脉注射。与对照组相比，冠状动脉疾病患者血浆中乳剂标记物的清除率（以分数清除率表示）较低（分别为0.019±0.005/分钟和0.036±0.018/分钟，P<0.05）。这些结果表明，冠状动脉疾病患者乳糜微粒残粒的清除速率较慢。
