Salerno S M, Strong J S, Roth B J, Sakata V
Department of Medicine, Madigan Army Medical Center, Tacoma, Washington 98431-5000, USA.
Am J Respir Crit Care Med. 1995 Dec;152(6 Pt 1):2170-2. doi: 10.1164/ajrccm.152.6.8520792.
Drug-induced eosinophilic lung disease commonly presents as a simple pulmonary eosinophilia-like syndrome consisting of transient pulmonary infiltrates, peripheral eosinophilia, and mild pulmonary symptoms that disappear promptly upon withdrawal of the offending medication. However, a more fulminant presentation most resembling acute eosinophilic pneumonia has been recently described. We present a patient with BAL-confirmed eosinophilic pneumonia (EP) and respiratory failure after a trazodone overdose. This is the first case of EP associated with trazodone and only the third drug-mediated EP reported to precipitate respiratory failure.
药物性嗜酸性粒细胞性肺病通常表现为一种简单的肺嗜酸性粒细胞增多样综合征，包括短暂性肺部浸润、外周血嗜酸性粒细胞增多以及在停用致病药物后迅速消失的轻度肺部症状。然而，最近已描述了一种更暴发性的表现，最类似于急性嗜酸性粒细胞性肺炎。我们报告了1例因曲唑酮过量导致经支气管肺泡灌洗术（BAL）确诊的嗜酸性粒细胞性肺炎（EP）并伴有呼吸衰竭的患者。这是首例与曲唑酮相关的EP病例，也是报告的第三例导致呼吸衰竭的药物介导性EP。
