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Different activities of impromidine and related phenyl-(pyridylalkyl)guanidines at cardiac and gastric H2 receptors.

作者信息

Coruzzi G, Adami M, Pozzoli C, Buschauer A, Bertaccini G

机构信息

Institute of Pharmacology, University of Parma, Italy.

出版信息

Inflamm Res. 1995 Apr;44 Suppl 1:S108-9. doi: 10.1007/BF01674420.

DOI:10.1007/BF01674420
PMID:8520976
Abstract
摘要

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Different activities of impromidine and related phenyl-(pyridylalkyl)guanidines at cardiac and gastric H2 receptors.脒基丁脲及相关苯基-（吡啶基烷基）胍在心脏和胃H2受体上的不同活性。
Inflamm Res. 1995 Apr;44 Suppl 1:S108-9. doi: 10.1007/BF01674420.
2
Effects of impromidine- and arpromidine-derived guanidines on recombinant human and guinea pig histamine H1 and H2 receptors.胍乙啶和阿普米定衍生胍对重组人及豚鼠组胺H1和H2受体的作用。
Arch Pharm (Weinheim). 2007 Jan;340(1):9-16. doi: 10.1002/ardp.200600140.
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Characterization of histamine H2-receptors in human neutrophils with a series of guanidine analogues of impromidine. Are cell type-specific H2-receptors involved in the regulation of NADPH oxidase?用一系列咪丁硫脲的胍类似物对人中性粒细胞中的组胺H2受体进行表征。细胞类型特异性H2受体是否参与NADPH氧化酶的调节？
Naunyn Schmiedebergs Arch Pharmacol. 1990 May;341(5):455-61. doi: 10.1007/BF00176340.
4
[Impromidine-analogous guanidines: synthesis and activity at the histamine H2-receptor. 29. Histamine analogs].
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5
[H2-antagonistic activity of the impromidine analog, cyanoguanidine. 37. H2 antihistaminics].[氰胍（一种英普咪定类似物）的H2拮抗活性。37. H2抗组胺药]
Arzneimittelforschung. 1988 Jan;38(1):7-10.
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Effects of histamine H2 receptor agonists and antagonists on the isolated guinea pig gallbladder.组胺H2受体激动剂和拮抗剂对离体豚鼠胆囊的作用。
Fundam Clin Pharmacol. 1999;13(1):84-90. doi: 10.1111/j.1472-8206.1999.tb00324.x.
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Synthesis and in vitro pharmacology of arpromidine and related phenyl(pyridylalkyl)guanidines, a potential new class of positive inotropic drugs.阿普米定及相关苯基（吡啶基烷基）胍类化合物的合成与体外药理学研究，一类潜在的新型正性肌力药物
J Med Chem. 1989 Aug;32(8):1963-70. doi: 10.1021/jm00128a045.
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Cardiovascular studies with impromidine (SK&F 92676), a new very potent and specific histamine H2-receptor agonist.使用新型强效特异性组胺H2受体激动剂英普咪定（SK&F 92676）进行的心血管研究。
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Specific activation of cyclic AMP-dependent protein kinase(s) by H2-histamine agonists in isolated gastric mucosal cells from guinea-pig.H2组胺激动剂对豚鼠离体胃黏膜细胞中环磷酸腺苷依赖性蛋白激酶的特异性激活作用。
Biochim Biophys Acta. 1980 May 22;629(3):604-8. doi: 10.1016/0304-4165(80)90165-8.
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Cardiac contractile and metabolic effects mediated via the myocardial H2-receptor adenylate cyclase system. Characterization of two new specific H2-receptor agonists, impromidine and dimaprit, in the guinea pig and human myocardium.通过心肌H2受体腺苷酸环化酶系统介导的心脏收缩和代谢效应。豚鼠和人心肌中两种新型特异性H2受体激动剂——英普咪定和二甲双咪的特性。
Res Exp Med (Berl). 1981;179(1):81-98. doi: 10.1007/BF01852128.

引用本文的文献

1
Cardiac and gastric effects of histamine H2 receptor antagonists: no evidence for a correlation between lipophilicity and receptor affinity.组胺H2受体拮抗剂对心脏和胃部的作用：没有证据表明亲脂性与受体亲和力之间存在相关性。
Br J Pharmacol. 1996 Aug;118(7):1813-21. doi: 10.1111/j.1476-5381.1996.tb15608.x.

本文引用的文献

1
Activity of the new histamine H2-receptor antagonist zolantidine at cardiac and gastric H2-receptors.新型组胺H2受体拮抗剂佐兰替丁对心脏和胃H2受体的作用。
Pharmacology. 1994 Feb;48(2):69-76. doi: 10.1159/000139164.
2
Action of histamine and of some H2-antagonists on gastric secretion 'in vitro'.组胺及某些H2拮抗剂对胃“体外”分泌的作用
Agents Actions. 1984 Apr;14(3-4):516-21. doi: 10.1007/BF01973862.
3
Cardiac effects of the new H2-receptor antagonists.新型H2受体拮抗剂的心脏效应。
Agents Actions. 1983 Apr;13(2-3):173-8. doi: 10.1007/BF01967325.
4
Correlation between log POCT/H2O and pKB estimates for a series of muscarinic and histamine H2-receptor antagonists.一系列毒蕈碱和组胺H2受体拮抗剂的即时检测（POCT）/水的对数与pKB估计值之间的相关性
Br J Pharmacol. 1988 May;94(1):264-74. doi: 10.1111/j.1476-5381.1988.tb11523.x.
5
Zolantidine (SK&F 95282) is a potent selective brain-penetrating histamine H2-receptor antagonist.佐兰替丁（SK&F 95282）是一种强效的、能穿透血脑屏障的选择性组胺H2受体拮抗剂。
Br J Pharmacol. 1988 Jan;93(1):69-78. doi: 10.1111/j.1476-5381.1988.tb11406.x.
6
Synthesis and in vitro pharmacology of arpromidine and related phenyl(pyridylalkyl)guanidines, a potential new class of positive inotropic drugs.阿普米定及相关苯基（吡啶基烷基）胍类化合物的合成与体外药理学研究，一类潜在的新型正性肌力药物
J Med Chem. 1989 Aug;32(8):1963-70. doi: 10.1021/jm00128a045.
7
Structure-activity relationships of histamine H2-agonists, a new class of positive inotropic drugs.组胺H2激动剂（一类新型正性肌力药物）的构效关系
Agents Actions Suppl. 1991;33:231-56. doi: 10.1007/978-3-0348-7309-3_15.