Stupp R, Vokes E E
Department of Medicine, University of Chicago, Illinois, USA.
J Infus Chemother. 1995 Spring;5(2):55-60.
5-fluorouracil is a widely used chemotherapeutic agent. Its role and activity in the treatment of squamous cell carcinoma of the head and neck are reviewed. In head and neck cancer, 5-fluorouracil is mostly used in combination with cisplatin. Despite a high activity of this regimen, as documented in response rates of up to 90%, its use as an adjuvant to surgery and radiation does not impact consistently on survival rates. In contrast, 5-FU-based chemotherapy with concomitant radiotherapy seems to improve treatment outcome. Several randomized trials suggest improved locoregional control with concomitant chemoradiotherapy with a 5-fluorouracil-based chemotherapy regimen. The activity and the metabolism of 5-FU can be further modulated by cisplatin, hydroxyurea, and leucovorin.
5-氟尿嘧啶是一种广泛应用的化疗药物。本文综述了其在头颈部鳞状细胞癌治疗中的作用和活性。在头颈部癌中，5-氟尿嘧啶大多与顺铂联合使用。尽管该方案活性较高，缓解率高达90%，但其作为手术和放疗的辅助治疗对生存率并无持续影响。相比之下，以5-氟尿嘧啶为基础的化疗联合放疗似乎能改善治疗效果。多项随机试验表明，采用以5-氟尿嘧啶为基础的化疗方案同步放化疗可改善局部区域控制情况。顺铂、羟基脲和亚叶酸可进一步调节5-氟尿嘧啶的活性和代谢。
