Rose J
Department of Biological Sciences, Idaho State University, Pocatello 83209, USA.
Comp Biochem Physiol C Pharmacol Toxicol Endocrinol. 1995 Jun;111(2):243-7. doi: 10.1016/0742-8413(95)00043-n.
The purpose of this study was to determine the effects of bilateral adrenalectomy on the time at which growth of the summer pelage begins in mink. Bilateral adrenalectomy of adult female mink between 2 and 11 March 1991, supplemented with deoxycorticosterone (DOC) as a mineralocorticoid, resulted in the onset of the summer fur growth approximately 5 weeks earlier than the controls (P < 0.01). Mink with their adrenal glands intact and treated with DOC, exhibited summer fur growth 2 weeks earlier than the controls (P < 0.01). The duration of time between the first observed hair growth and attainment of maximal guard hair length, was approximately 10 days longer in mink with their adrenal glands intact and supplemented with DOC than the controls (P < 0.05). Adrenalectomized mink treated with DOC exhibited guard hair growth for approximately 13 days longer than controls (P < 0.05). Although exogenous DOC initiated hair growth, the rate of growth appeared to be reduced. These data suggest that adrenal hormones, of undetermined identity, exert a tonic inhibitory effect on the initiation of summer fur growth in mink and may be part of the mechanism through which changes in photoperiod regulate the onset of hair growth cycles.
本研究的目的是确定双侧肾上腺切除术对水貂夏季被毛开始生长时间的影响。1991年3月2日至11日对成年雌性水貂进行双侧肾上腺切除术，并补充脱氧皮质酮（DOC）作为盐皮质激素，结果发现夏季毛发生长开始的时间比对照组早约5周（P<0.01）。肾上腺未切除但接受DOC治疗的水貂，其夏季毛发生长比对照组早2周（P<0.01）。肾上腺未切除且补充DOC的水貂，从首次观察到毛发生长到达到最大针毛长度的持续时间，比对照组大约长10天（P<0.05）。接受DOC治疗的肾上腺切除水貂，其针毛生长时间比对照组大约长13天（P<0.05）。虽然外源性DOC启动了毛发生长，但生长速度似乎有所降低。这些数据表明，身份未明的肾上腺激素对水貂夏季毛发生长的启动具有紧张性抑制作用，可能是光周期变化调节毛发生长周期开始的机制的一部分。
