Rose J, Kennedy M, Johnston B, Foster W
Department of Biological Sciences, Idaho State University, Pocatello 83209, USA.
Comp Biochem Physiol A Mol Integr Physiol. 1998 Nov;121(3):263-71. doi: 10.1016/s1095-6433(98)10127-7.
We investigated the relationship between serum concentrations of prolactin (PRL) and dehydroepiandrosterone (DHEA) during initiation and development of summer and winter hair growth (anagen) cycles in mink. In the spring, haloperidol (HAL) increased PRL concentrations and induced summer anagen earlier than controls, whereas melatonin (MEL) inhibited PRL secretion and completely blocked summer anagen. In the fall, HAL increased PRL concentrations, inducing anagen at an earlier time than controls, although the resulting fur was abnormal being almost devoid of underhair fibers. Exogenous MEL during the fall reduced PRL concentrations, initiating winter anagen 4 weeks earlier than controls. Adrenalectomy (ADX) induced earlier onset of summer and winter anagen and neutralized the inhibitory effects of HAL in the fall and MEL in the spring. No change in serum DHEA concentrations was observed during the onset of summer or winter anagen in any group although MEL increased DHEA levels from 27 March through 5 June relative to HAL-treated mink. We conclude that changes in serum levels of DHEA and PRL are not requisite to onset of summer or winter anagen in mink. It is possible that metabolites of DHEA and/or PRL may still affect other aspects of the hair growth cycle.
我们研究了水貂夏冬毛发生长期（生长期）开始和发展过程中血清催乳素（PRL）和脱氢表雄酮（DHEA）浓度之间的关系。在春季，氟哌啶醇（HAL）提高了PRL浓度，并比对照组更早地诱导夏毛发生长，而褪黑素（MEL）抑制PRL分泌并完全阻断夏毛发生长。在秋季，HAL提高了PRL浓度，比对照组更早地诱导毛发生长，尽管长出的毛不正常，几乎没有绒毛纤维。秋季外源MEL降低了PRL浓度，比对照组提前4周开始冬毛发生长。肾上腺切除术（ADX）使夏冬毛发生长提前开始，并抵消了秋季HAL和春季MEL的抑制作用。在任何组中，夏冬毛发生长开始时血清DHEA浓度均未观察到变化，尽管相对于接受HAL处理的水貂，从3月27日至6月5日，MEL使DHEA水平升高。我们得出结论，血清DHEA和PRL水平的变化对于水貂夏冬毛发生长的开始并非必要。DHEA和/或PRL的代谢产物仍有可能影响毛发生长周期的其他方面。
