Higuchi M, Arita N, Ohnishi T, Hiraga S, Kusakabe M, Sakakura T, Hayakawa T
Department of Neurosurgery, Osaka University Medical School, Japan.
Clin Neuropathol. 1995 Jul-Aug;14(4):223-7.
Immunohistochemical expression of tenascin (TN) and glial fibrillary acidic protein (GFAP) was investigated in 9 human malignant gliomas with leptomeningeal dissemination. In these patients intracerebral glioma tissues obtained at operation and/or autopsy displayed localized expression of TN in tumor vessels and stroma. In contrast, TN was expressed in the tumor vessels, tumor stroma, and the cytoplasm of tumor cells to a high degree throughout all the leptomeningeal tumor tissues obtained at autopsy, whereas there was much less expression of GFAP in these tissues than at the primary site. These findings suggest that TN expression and decrease of GFAP expression in glioma tissue may be involved in the development of leptomeningeal dissemination.
研究了9例伴有软脑膜播散的人类恶性胶质瘤中腱生蛋白（TN）和胶质纤维酸性蛋白（GFAP）的免疫组化表达。在这些患者中，手术和/或尸检获取的脑内胶质瘤组织显示TN在肿瘤血管和间质中有局限性表达。相比之下，尸检获取的所有软脑膜肿瘤组织中，TN在肿瘤血管、肿瘤间质以及肿瘤细胞的细胞质中均有高度表达，而这些组织中GFAP的表达比原发部位少得多。这些发现表明，胶质瘤组织中TN的表达及GFAP表达的降低可能与软脑膜播散的发生有关。
