Mudun A, Unal S, Aktay R, Akmehmet S, Cantez S
Department of Nuclear Medicine, Istanbul University, Faculty of Medicine, Turkey.
Clin Nucl Med. 1995 Sep;20(9):772-8. doi: 10.1097/00003072-199509000-00004.
The aim of this study was to compare Tc-99m nanocolloid scintigraphy with Tc-99m MDP bone imaging in the diagnosis of osteomyelitis and septic arthritis. Overall, 31 Tc-99m MDP bone scans and 39 Tc-99m nanocolloid studies were performed in 34 patients (15 female, 19 male; mean age, 14.88 years +/- 19.00 years) who were suspected of osteomyelitis and/or septic arthritis. The final diagnoses were established by needle aspiration, cultures, radiography, clinical course, and, in some patients, with CT, ultrasonography, and biopsy. The sensitivity, specificity, and accuracy were 100%, 75%, and 92%, respectively for both Tc-99m MDP and Tc-99m nanocolloid scans in detecting osteomyelitis. For septic arthritis, Tc-99m MDP bone imaging showed 100%, 85%, and 94%, and Tc-99m nanocolloid scans showed 90%, 59%, and 76%, sensitivity, specificity, and accuracy, respectively. These results show that, although both scans are in good agreement for osteomyelitis, for septic arthritis nanocolloid is not specific enough to recommend it to be a complementary method to MDP bone scans.
本研究旨在比较锝-99m纳米胶体闪烁扫描术与锝-99m亚甲基二膦酸盐（MDP）骨显像在骨髓炎和化脓性关节炎诊断中的应用。总体而言，对34例疑似骨髓炎和/或化脓性关节炎的患者（15例女性，19例男性；平均年龄14.88岁±19.00岁）进行了31次锝-99m MDP骨扫描和39次锝-99m纳米胶体研究。最终诊断通过针吸活检、培养、放射照相、临床病程确定，部分患者还采用了CT、超声检查和活检。在检测骨髓炎方面，锝-99m MDP和锝-99m纳米胶体扫描的敏感性、特异性和准确性分别为100%、75%和92%。对于化脓性关节炎，锝-99m MDP骨显像的敏感性、特异性和准确性分别为100%、85%和94%，锝-99m纳米胶体扫描分别为90%、59%和76%。这些结果表明，虽然两种扫描在骨髓炎诊断上一致性良好，但对于化脓性关节炎，纳米胶体的特异性不足，不足以推荐其作为MDP骨扫描的补充方法。
